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DISCUSSION Oxidative stress is a major pathogenetic event occurring in several liver disorders ranging from metabolic to proliferate ones, and is a major cause of liver damage in Ischemia/Reperfusion during liver transplantation

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With subgroup comparisons, we discovered that decreased DNA methylation and increased mRNA expression of GSTA4 were associated with the risk of IA in women but not in men

Accumulated evidences have shown that urolithin A exhibits multiple protective effects inducing mitophagy in heart (Huang et al., 2022c), muscle (Luan et al., 2021) and brain (Jayatunga et al., 2021)

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