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ALA therapy is approved as a pharmacological treatment for DPN in several European countries

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have shown that, under normoxia, ES2 cells are more resistant to carboplatin than OVCAR3 and that the inhibition of GSH production by buthionine sulphoximine (BSO), sensitizes ES2 cells to carboplatin 23

To carry out the substitution, it was proposed to separate the skeleton into a triazole nucleus, an aromatic nucleus and an isobutane group, whose respective substitutions are isatin, triazole and indole