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doi: 10.22074/ijfs.2020.44411

Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease

GLP-1, however, engages the GLP-1R/ERK1/2/HDAC6 axis to modulate downstream transcriptional activity, it lowers intracellular ROS, reduces Akt and ERK1/2 phosphorylation, restores HDAC6 expression, and thereby alleviates endothelial dysfunction and excessive autophagy (Zummo et al., 2017)

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Sep 1980;42(5):493-497

Ozempic Novo Nordisk semaglutide Active molecule Semaglutide Receptor activity GLP-1 Primary indication Type 2 diabetes Max maintenance dose 1.0 mg weekly (some up to 2.0 mg) Avg