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Dihexas protection from acute but not chronic aminoglycoside exposure further strengthens the two-phase model of aminoglycoside induced-hair cell death

In addition to damaging lipids, large amounts of ROS disrupt endoplasmic reticulum homeostasis and lead to the accumulation of misfolded and unfolded proteins, activating unfolded protein responses and triggering endoplasmic reticulum stress (ERS) [85]

The latter is a major antioxidant and plays an important role in the maintenance of the redox status of the cell and in protecting against oxidative damage by reactive oxygen species (Wang and Ballatori, 1998)

However, as the results could not be reproduced by other groups [164], it was finally realized that the authors of the original study dissolved APAP in DMSO instead of saline

It also helps detoxify chemicals, including some that your body creates naturally, as well as pollutants and drugs

It plays an essential role in collagen production, skin elasticity, and tissue regeneration