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The starting date was when semaglutide was approved in the US for weight management as Wegovy

A GLP-1 creates a caloric deficit and the body fills that deficit by burning fat, but the order matters: visceral fat goes first, then non-lipedema subcutaneous fat, then lean tissue under prolonged restriction

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This process is marked by a substantial accumulation of ROS, triggered through the activation of the KEAP1PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5)AIFM1 signaling cascade (Fig