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Individuals with Wilsons Disease or other copper metabolism disorders should avoid GHK-Cu entirely

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Gan L, Qian M, Shi K, Chen G, Gu Y, Du W, Zhu G

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Therefore, the purpose of this scoping review is to characterize the current evidence base for peptide therapies relevant to musculoskeletal care, with emphasis on BPC-157, thymosin beta-4 derivatives, and related agents, and to define safety considerations and perioperative implications for orthopaedic surgical patients, including those undergoing TJA

For instance, it upregulates the microRNA-34a/449a cluster, which targets anti-apoptotic proteins like Bcl-2 and Notch1 [196]