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On the other hand, ACE2 enables virus entry into host target cells [67], raising speculation of augmented vulnerability to SARS-CoV-2 infection in the case of ACE2 overregulation, as an outcome of long-term treatment with ACE inhibitors and/or ANGII receptor blockers, GLP1-RAs or a combination of both in hypertensive patients with diabetes [68]

When two or more doses of the medication are skipped, a person can lose tolerance, increasing the risk of severe side effects once the GLP-1 receptor agonist is resumed

Li Q, Liu Y, Sun M

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10.1016/s0140-6736(70)91347-4 Lancet 177 StinsonL

UK Prospective Diabetes Study (UKPDS) Grou