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Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops

So, why might they happen in the first place

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But, despite the lack of veterinary research justifying the pre-CHF dosing of these drugs, it unquestionably has become the mainstream way to treat mitral valve disease these days

Circadian rhythm disruption will lead to cellular dysfunction, which in turn affects the metabolic function of the liver (115)