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Where estrogen works to restore the hormonal environment that governs fat distribution and metabolic regulation, GLP-1 therapy directly reduces caloric intake by recalibrating appetite signaling, improves glycemic control through multiple mechanisms, and drives the reduction of visceral fat mass that estrogen alone cannot reliably produce in the setting of significant metabolic burden

The Clinical Reality: The "Bioavailability Problem" Here is where the clinical reality diverges from the headline

Tell your doctor if you have iron or folic acid deficiency