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Ao T, Kikuta J, Ishii M

Significant reductions in subcutaneous fat can alter skin tension, hydration, and barrier function, which may manifest as dryness, sensitivity, or a sensation of tightness

This interaction stimulates collagen production, which is vital for maintaining skin elasticity and firmness (1)

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Whereas creatinine-based estimates of GFR are able to predict risks associated with declining kidney function when eGFR levels fall to 60 mL/min/1.73m2 or less, GFR estimates based on cystatin C level are predictive at approximately 85 mL/min/1.73m2

Chen LL, Zheng JH (2021) Effects of atorvastatin on the insulin resistance in women of polycystic ovary syndrome: A systematic review and meta-analysis: A systematic review and meta-analysis