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The thumb must face the groin, while the rest of the fingers face the head

Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, et al

2012 Nov;15(6):637-46

Although regulation by redox environment occurs in the heterodimeric non-plant eukaryotic GCL, the plant GCL function as homodimeric enzymes with two intermolecular (not intramolecular) disulfide bonds (Hothorn et al., B

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Biosci Biotechnol Biochem 61:19771980