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Positive correlations of circulating DPP4 with the extent of adipocyte hypertrophy, macrophage infiltrations, and insulin resistance were observed in insulin-resistant morbidly obese patients (49)
The most plausible hypothesis of the mechanism whereby ectopic lipid accumulation induces insulin resistance is that several lipid metabolites, including diacylglycerol (DAG), lysophosphatidic acid (LPA), ceramides, and acylcarnitines, are involved in the pathogenesis of insulin resistance in liver and skeletal muscle
Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin
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The test analyzes 14 metabolic pathways and 150+ genetic insights, including GLP1R rs6923761, FTO rs9939609, and MC4R rs17782313 variants
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