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These aberrant modifications deeply engage in the inflammatory cascade, oxidative stress, cardiomyocyte apoptosis, and subsequent ventricular remodeling primarily by modulating the transcriptional activity of specific genes 76

Chitosan, a commonly used mucoadhesive polymer, exemplifies this approach and is typically attached to particle surfaces either through chemical conjugation or physical adsorption 135,136,137

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Stimulating telomerase activity , the enzyme responsible for maintaining and elongating telomeres