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Importantly, the timing and location of PROTAC release in these nanomaterial-based delivery systems depend strongly on carrier composition and trigger mechanism

This personalized approach increases the likelihood of sustainable weight loss and metabolic improvement compared to trial-and-error supplementation

The 5 mg/kg intraperitoneal dosing regimen (three times weekly) established the preclinical dosing framework for subsequent research

This variability likely reflects heterogeneity in the biological drivers of obesity across individuals, suggesting opportunity for precision medicine approaches that match patients to optimal therapeutic mechanisms

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