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One mechanism by which butyrate may function is to inhibit the activation of the proinflammatory cellsignaling component nuclear factor kappa B (NF-kB) (Segain 2000)

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J Food Sci 83(2):552558

A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR

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