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Mediation analysis showed that changes in glycated hemoglobin accounted for only 2.4% to 6.5% of the effect, depending on the comparison group, while changes in body mass index (BMI) accounted for just 0% to 0.7%
There is no established evidence supporting the combined use of orlistat and Wegovy, and this combination is not recommended in standard clinical practice
There is emerging evidence that supports the active role of GLP1R signaling pathways in microvascular function and blood pressure control
Statements Author contributions SZ read the literature related to the topic and participated in drafting the manuscript