Oral formulations exist, though most clinical protocols use subcutaneous injection because it delivers more predictable dosing
And so that is why I see a lot of people at my gym getting the knee replacements, the shoulder surgeries, the things that they don't necessarily need to have on a daily basis in terms of functioning
We propose that differential cytokine exposure, intrinsic bioenergetic vulnerability, and bloodbrain barrier integrity could contribute to region-specific susceptibility, although direct CNS profiling will be required to test this hypothesis
And that's why this could be so powerful
At 20 mg/kg, we observed a 4-fold increase with ~13% gametocytemia
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