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While ionic copper can promote oxidative damage through Fenton reactions, GHK-Cu is studied as a protected copper delivery systemthe peptide binds copper tightly, preventing redox cycling while delivering it to cells in a bioavailable form

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Foundational Discovery Selective Senolytic Elimination in Aged Mice (Cell, 2017 Baar et al.) FOXO4-DRI Restores Fitness, Fur Density, Renal and Liver Function in Aged Mice The foundational study introducing FOXO4-DRI as a senolytic peptide was published in Cell by Baar and colleagues in 2017

Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatotic liver disease