The ones who benefit most are those with elevated baseline ALT, visible hepatic steatosis on imaging, or mid-afternoon fatigue that doesn't resolve with caffeine
10.1038/377209a0 46 WolfeL
Oral MTX responsiveness can be enhanced by administering a large starting dose and rapidly titrating the medication
Research now suggests that it can have a powerful effect on protecting and healing damaged digestive tissue: its been found to inhibit the formation of lesions in the esophagus, stomach, and duodenum
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If you miss more than two consecutive weeks, you may notice a dip in energy or metabolic responsiveness, particularly if you were experiencing noticeable benefit before the gap