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Moreover, when metformin was combined with a DPP-4 inhibitor, concentrations of intact GLP-1 were increased beyond those observed with the DPP-4 inhibitor alone [51]

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Research has shown that newer medications, such as semaglutide and tirzepatide, often yield better results for weight loss and glycemic control compared to older agents like liraglutide and dulaglutide

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