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The GLP-1RAs-associated weight loss is thought to be achieved through a variety of mechanisms, including the delayed gastric emptying, increased satiety, increased resting energy expenditure, as well as the direct influence of the appetite center of the brain (175)

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For hepatocyte-specific Gdh1 deletion, Glud1 fl/fl mice received a tail-vein injection of AAV8-TBG-GFP (Addgene, 105535) or AAV8-TBG-Cre (1.5 10 11 genome copies per mouse

Furthermore, the ATF4/MAP1LC3A/CCPG1 pathway may induce apoptosis via ER autophagy activation ( Regulatory factors in the ovarian microenvironment, such as estradiol (E 2 ), insulin-like growth factor (IGF) (Monniaux and Pisselet, 1992), FSH, and epidermal growth factor (EGF) (Tilly et al., 1992