When used in topical formulations, the most commonly reported issues are localised and mild, and may include: Skin irritation or redness at the site of application Contact dermatitis in individuals with sensitive skin or known peptide sensitivities Scalp itching or tingling , which may be transient The following precautions are advised: Avoid application to broken, inflamed, or irritated skin , and keep the product away from the eyes and mucous membranes
Wu, J.-H
Unlike blood-flow medications such as PDE5 inhibitors, PT-141 influences brain activity linked to sexual motivation and reward, not vascular function
Its supporting evidence is animal and cell-culture research, which is genuinely interesting for understanding mechanism but doesn't establish human safety or efficacy at any particular dose
Notes: The weekly dose of 15mg should not be exceeded
The drugs are generally well-tolerated, however, infrequent and transient, dose-related side effects may occur