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While the sample is small (6 patients), it represents an important step in the evidence chain: moving from laboratory proof-of-concept to human clinical testing

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10.1053/j.semperi.2018.05.007 47 JiL.JiangP.LuB.ShengY.WangX.WangZ

Research has demonstrated that the compound shows anti-proliferative activity in specific cancer cell lines, with HeLa cells showing concentration and time-dependent growth inhibition across a 0.1-500 M range while HEK-293 cells remain unaffected

[9] Concomitant administration of large calcium supplements, thiazide diuretics, or aluminium-containing phosphate binders can potentiate vitamin D-mediated increases in serum calcium or phosphate, demanding periodic laboratory monitoring and dosage adjustments to avert nephrolithiasis or ectopic calcification