Under pathological conditions, FUNDC1 persists in a phosphorylated state that specifically impedes its molecular interaction with the autophagosomal marker protein LC3-II, consequently suppressing mitophagy initiation and ultimately inducing neuronal dysfunction ( Mitochondrial fragmentation has also been demonstrated in AD patients and model animals
Cell Metabolism , 27(6), 1212-1221
All those properties led to the development of many applications in the food and chemical industries but also in the medical and therapeutic field
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