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doi: 10.1016/0014-5793(95)01006-Z 119 FalkoJMCrockettSECatalandSMazzaferriEL
first published clinical evidence on the efficacy of liraglutide in the treatment of MC4R -deficient obesity [67]
16.58% for the insulin degludec group)
We conducted a comprehensive literature search across databases, including PubMed and Web of Science, compiling data from clinical trials, case reports, and basic research studies published up to 2025, with a focus on the efficacy, safety, and mechanism of action of drugs such as liraglutide, semaglutide, and tirzepatide in patients with MC4R deficiency
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