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Therefore, the sensitivity and specificity of current responsive chemistries still require improvement, and the operability and safety of external stimuli in routine clinical settings remain to be fully validated

However, depletion of another -KG-producing enzyme, PSAT1, but not GDH1 greatly reduced AMPK expression in IMR90 cells (Supplementary Fig

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Although some of the metabolic benefits conferred by bariatric surgeries have been ascribed to changes in the secretory profiles of various gut hormones, the therapeutic potential of the enteroendocrine system as a viable target against metabolic diseases remain largely underexploited, except for incretin-mimetics

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