Creatine is one of the most widely studied supplements on the market, with decades of clinical research to demonstrate its effectiveness and safety
The data revealed that the members on microdoses encountered destabilizing side effects
van Poelgeest et al., 2015
The combination of these therapies is mechanistically appealing and may offer incremental benefit in selected patients with overlapping metabolic, renal, and cardiovascular risk
According to reports, curcumin is a P450 inhibitor that inhibits CYP2C9, CYP1A2, CYP2D6, CYP2B6 and CYP3A4, with particularly low IC50 values for CYP2C9 (Sasaki et al., 2017)
An ethical consultation should make room for a patient to decline treatment