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Split dosing (administering the daily total in two doses separated by 8-12 hours) maintains more consistent tissue levels and may benefit acute injuries where steady peptide presence supports ongoing healing processes
When added to cytosolic extracts of mouse adipose tissue, CGI-58 stimulated lipolysis, while purified CGI-58 exhibited no lipase activity in vitro
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M.NegreaA.CiopecM.DueanuN.et al
This decrease was more pronounced when adipocytes from HSL-null mice were utilized, a finding that suggests cooperativity exists between the two enzymes, and indeed, a synergistic effect has been observed on lipolysis when cells are cotransfected with both desnutrin/ATGL and HSL (144)
The acidity of gastric juice can vary from pH 1 to pH 7 or even more
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