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Originally developed as an anti-obesity therapeutic, it has a strong safety profile from Phase II clinical trials and was even granted GRAS (Generally Recognised as Safe) status by the FDA for use in food products making its Category 2 classification particularly puzzling

These potent GSTO1 inhibitors suppress cancer cell growth, enhance the cytotoxic effects of cisplatin and inhibit tumour growth in colon cancer models as single agent

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Meth Enzymol 113: 484490

[298] The stratification of results by age and mental health diagnosis, as well as standardization of measure performance scores by volume, is sufficient to account for differences between hospitals without further need for risk adjustment