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Gallbladder disease and modest increases in heart rate were also observed

PMID: 9479010

Meta-analyses of these and other studies have demonstrated: Reductions in total cholesterol typically in the range of 15% from baseline, varying by agent and population Decreases in LDL cholesterol ranging from 17%, generally more modest than dedicated lipid-lowering therapies Reductions in triglycerides of 515%, with greater effects often seen in those with higher baseline levels Variable effects on HDL cholesterol , with small increases (1-2%) or neutral effects reported The magnitude of lipid improvements appears to correlate with the degree of weight loss achieved, suggesting that metabolic benefits may be partially mediated through adiposity reduction

The bottom of that curve should align with your target line

they represent a fundamentally different approach to weight management

This gut-derived hormone enhances glucose-dependent insulin secretion, suppresses glucagon secretion, delays gastric emptying, and promotes satiety