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Diabetes Obes Metab 2018;20:22382245 [DOI] [PMC free article] [PubMed] [Google Scholar] 18

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The primary concern involves shipping during extreme cold or heat, where freeze-thaw cycles could damage peptide integrity

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wet granulation is accomplished using water or organic liquids such as acetone, di- n- butyl ether or alcohols containing about 1-8 carbon atoms, e.g., methanol, ethanol, n -propanol, i -propanol, n butanol, i -butanol, t -butanol, n -pentanol, i -pentanol or a mixture thereof

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