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Consequently, while triple agonists represent an important advancement in obesity pharmacotherapy, their safety, tolerability, and long-term developmental effects in adolescents remain unknown

One study found that even at 1 mg doses, postmenopausal women achieved weight and fat loss comparable to premenopausal women, despite having higher baseline weight and fat mass

Retatrutide Phase 2 RCT (human): Jastreboff et al., Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for type 2 diabetes, The Lancet , 2023 PubMed

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Stay consistent with recommended IV sessions for long-term benefits

These effects may benefit patients with binge eating disorders but could exacerbate restrictive behaviors in those with anorexia nervosa