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Diabetes guidelines from major organizations support adding SGLT-2 inhibitors and/or GLP-1 agonists to metformin therapy for patients with type 2 diabetes and established CVD, 510 and most guidelines support their use in patients at high risk of cardiovascular events

Liraglutide could also improve hepatic steatosis and ballooning degeneration in patients with NASH (192)

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A second class of chemosensory receptors in the olfactory epithelium

Understanding that nausea occurs in about 20% of users, particularly with higher doses, is essential

Adjusting frequency or timing may help some patients, though dose reduction typically diminishes weight loss benefits