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Research on peptide reconstitution techniques has observed that mechanical stress such as vigorous shaking or direct injection onto the powder causes aggregation and structural changes that cannot be reversed

[DOI] [PMC free article] [PubMed] [Google Scholar] Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, Abete P

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Previous attempts at treatment and the severity of tissue damage also matter

doi: 10.32474/OAJESS.2019.02.000144 68