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As cell mass continues to decrease, the increased metabolic demand, continuous exposure to pro-inflammatory cytokines, and sustained hyperglycemic conditions upregulate mitochondrial and ER stress in cells, which further impair cell function and promote stress-mediated stress (179188)

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Christensen MB, Lund AB, Jrgensen NR, Holst JJ, Vilsbll T, Knop FK (2020) Glucose-dependent insulinotropic polypeptide (GIP) reduces bone resorption in patients with type 2 diabetes

Research suggests aiming for about 1.2 grams per kilogram of body weight

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Front Neurol 2019, 10, 755