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These modifications result in increased self-association, binding to albumin, and a longer half-life [20]

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Further investigations to fully elucidate the effect of the V229A substitution on GLP-1R-cholesterol interactions might include detailed atomistic MD simulations of WT versus V229A receptors, as well as resolving cryo-EM structures of mutant and WT receptors in nanodiscs containing relevant lipid compositions to preserve receptor-lipid interactions in their native environment

P., Burman, D., Tannock, I