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Key areas of scientific investigation include: The role of GLP-1 signaling in modulating dopamine release and reward sensitivity Potential effects on motivation, reinforcement, and impulse-driven behavior Overlap between neural pathways involved in appetite regulation and substance use Much of the early evidence comes from preclinical animal studies

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You'd be surprised how much mental load that removes when you're already navigating a new city, a new currency, and a new climate

The FLOW trial (Perkovic et al, NEJM 2024) was a phase 3 randomized trial, of 3,533 patients with type 2 diabetes and CKD (eGFR 50-75ml/min or 25-50 ml/min with albuminuria) who received 1 mg of subcutaneous semaglutide weekly, or placebo

others stay on a maintenance dose longer