GLP-1 also helps slow down digestion
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"Mazdutide (IBI362), a GLP-1/glucagon receptor dual agonist, in Chinese adults with overweight or obesity: a randomised, placebo-controlled, multiple-ascending-dose phase 2 trial." EClinicalMedicine 59 (2023)
While retatrutide microdosing has not been formally studied for GI mitigation specifically, the principle is sound based on the dose-response data from clinical trials
It shows relatively low acute toxicity
I inject every Saturday morning now while my husband handles breakfast with the kids