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In light of the narrow therapeutic window defined by the balance between glucose-lowering efficacy and (so-called) gastrointestinal side effects, it seems unlikely that future long-acting GLP-1 receptor agonists will provide substantially greater efficacy without inducing more side effects compared with the already available compounds

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If your liver is stressed from alcohol, medication, or unhealthy food, it may not work correctly

Risks Related to Long-Term or Unsupervised Use The long-term safety of many peptides is still being studied