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Can GLP-1 medications make dehydration worse

Hepatokine ITIH3 protects against hepatic steatosis by downregulating mitochondrial bioenergetics and de novo lipogenesis

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Reiber C, Brieger A, Engelhardt G, Hebel S, Rink L, Haase H

Lancet 10140 , 26072618 (2018)

It requires taking on a completely empty stomach with no more than 4 ounces of water, then waiting 30 minutes before eating or drinking anything else