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Endothelial injury generated directly by intracellular viral replication and by ACE2 downregulation, exposing cells to angiotensin II in the absence of the modulator effects of angiotensin 17 (270, 271), and vascular chronic inflammation promoting the development of tissue macrophages overloaded by cholesterol (foam cells), both increase the possibility of acquiring a severe COVID-19 infection (170, 209, 258, 259, 272, 273)

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Lowering the risk of autism spectrum disorder with folic acid: can there be too much of a good thing?. The American Journal of Clinical Nutrition 115.5 (2022): 1268-1269

National Center for Health Statistics