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Comparative efficacy across agents semaglutide , dulaglutide , liraglutide , exenatide , lixisenatide , tirzepatide was linked to real-world outcomes, including CVOT findings (REWIND, LEADER, SUSTAIN-6, PIONEER) and FLOW -derived nephroprotection

Preclinical studies indicate that GLP-1 receptor agonists reduce not just alcohol intake, but also nicotine self-administration and nicotine-related reward, Hendershot noted

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The comparison of these two forms of semaglutide is critical in understanding the potential trade-offs between convenience and therapeutic effectiveness