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Contraindications exist even for adults over 18

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Gastrointestinal Symptoms: The gastrointestinal tract is densely populated with histamine H2 receptors, and excess histamine stimulates gastric acid secretion, increases intestinal motility, and disrupts the intestinal epithelial barrier

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A recent meta-analysis of 11 cardiovascular outcome trials involving 55,921 patients treated with GLP-1 RAs and 43,306 patients treated with DPP-4 inhibitors also revealed no significant association between either drug class and pancreatic cancer risk