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Therefore, while GLP-1RAs may represent a promising therapeutic option for managing psoriasis, further high-quality studies are needed to distinguish whether the therapeutic effects of GLP-1RAs originate from the direct regulation of immune cells or improvements in comorbidities such as obesity or diabetes

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a meta-analysis has demonstrated that single nucleotide polymorphisms (SNPs) in these genes can affect plasma UA concentrations 24

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The analysis included an assessment of the microbial composition of metformin-treated mice and the biosynthetic activity of specific metabolites