Looking ahead, employers may continue to face the competing pressures of employee demand for GLP-1 drugs and concerns about costs
Obesity and related diseases, including cardiovascular disease, hypertension, and type 2 diabetes, are leading causes of death in the U.S
Its activation of three key hormone receptors makes it distinct from other weight loss medications and capable of achieving significant weight loss through improved glucose, insulin, and fat metabolism regulation
This class of drugs has also been found to lower the risk of cardiovascular disease and certain cancers
26,27 Drug Efficacy and Side Effects in Clinical Trials The first GLP-1RA that received FDA approval was put on the market in 2005 under the name exenatide
In this Perspective, we summarize data on cancer incidence from trials and registries in individuals with type 2 diabetes, describe the actions of GLP-1 medicines on preclinical cancer models and highlight possible direct and indirect mechanisms linking GLP-1R signaling to cancer development and progression