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Hypoglycemia: When used with other medications that increase insulin levels, such as sulfonylureas, the risk of hypoglycemia (low blood sugar) increases

For instance, dose reduction rather than complete cessation might resolve side effects whilst maintaining some therapeutic benefit

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Jepsen, S

GLP-1 receptor agonists , by substantially improving insulin sensitivity and reducing postprandial glucose excursions, lower the ambient insulin and IGF-1 environment effectively reducing a critical fuel source exploited by malignant cells

When progress inevitably slows, the contrast feels jarring even though the slowing represents normal, healthy weight loss patterns