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If confirmed severe gastroparesis is attributed to GLP-1 therapy, medication discontinuation is generally recommended, with most patients experiencing gradual symptom improvement over weeks to months

and 2) a trial-product estimand which includes data collected from all randomized participants prior to premature trial-product discontinuation or initiation of rescue medication ( SIDEBAR 2 )

Back Freudenthal, R, Moncrieff, J (1 March 2022) '"A landmark in psychiatric progress"

For 95% of patients who need treatment in 2026 or 2027, tirzepatide is the right choice not because it's the better drug on efficacy, but because it's the drug that exists right now

Microdosing usually means taking a tiny fraction of a typical dose of a drug to get subtle effects

Richy FF, Sabid-Espin M, Guedes S et al