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52 Synergistic activation of vagus nerve afferents by both cholecystokinin and leptin mediates their short-term inhibitory effects on food intake

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Overeating is linked to a malfunction in the hypothalamic arcuate nucleus, which is where neuropeptide Y (NPY), agouti-related peptide (AgRP), proopiomelanocortin (POMC), and leptin interact to regulate food intake and body weight