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Nat Rev Mol Cell Biol

A: Yes, it matters significantly

While some patients experience diarrhea, others develop constipation, and many notice changes in bowel frequency or consistency

The PK profiles of intact and total AMG 133 demonstrate similar initial concentrations between assays with a gradual divergence over the 5-week study period

doi: 10.1016/S0021-9258(18)42531-8 84 ChenYEDruckerDJ

Diarrhea on tirzepatide can cause dehydration and electrolyte imbalances that promote water retention