Compared to GLP-1RAs, SGLT2is are associated with an overall modest mean weight loss of 23 kg [20]
Participants who followed the recommended dose escalation timeline (rather than staying at lower doses) achieved the best results
They have not been studied in the clinical trials behind those medications
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Individual results may vary based on numerous factors including genetics, adherence, lifestyle, and concurrent health conditions.
The degree of semaglutide-induced weight loss in this study exceeded the EMA and FDAs criteria for anti-obesity drugs and there were no safety concerns, indicating the potential of once-daily subcutaneous semaglutide as an anti-obesity drug in the future
